Multiplexed ONCYTE protein microarrays used for infectious disease immunogen discovery.
Friday, October 16, 2015 5:44:40 AM
First, in an interesting Shistotosomiasis study, Gaze, et al, employ protein microarrays in a longitudinal immunomics study for vaccine antigen discovery. Schistosomiasis is a pervasive disease affecting 200 million people a year and traditional drug treatments are ineffective due to re-infection, drug expense, and parasite drug resistance. Non-sterile immunity does develop over long periods of exposure. However, protection of high risk groups such as children will benefit from vaccination. Vaccine development has encountered difficulties due to the parasite’s outer covering to which the host commonly produces an immune response. Using microarrays to screen for IgG and IgE responses from the sera of resistant individuals, the group was able to develop a method for identification of complete sets of humoral immune responses to epitope phenotypes of this parasite.Read More
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